I'm back from my trip. I was very pleased with Topo USA 7.0. I started out using the 3D feature on the left side of the screen, but found the 3D to be less than useful much of the time...ended up using 2D in both panes, but at different scales. I also ran Street Atlas USA for a broader scale, and would simply click between the two programs without having to change the scales. I found the topographic information very useful while rolling through the Appalachians, Rockies, Sierra Nevada and Cascades...no great advantage on flat land, though!
I was less than happy with the performance of the Earthmate LT-20 GPS receiver (USB connection). It took a very long time to obtain initial position fixes...regularly as much as 30-45 minutes. I did everything possible to optimize the receiver position on the window, using various supports, tape, aspects and locations on 5 different trains. I don't recall having such long waits when using on my old (now dead) XP machine...could Vista be the culprit? Once locked in it would usually track well, though terrain and vegetation would often cause a position loss. Tunnel problems were, of course, expected.
I see that Delorme now offers an LT-40...I wonder if it has better sensitivity that the LT-20. I have also been spoiled with my Garmin nuvi 670 for use in the car...very senitive, rapid reception and position fixing...even indoors! I'll have to try that on a train (if I can get it away from my wife!). Of course it lacks topo data.