Keeping medication cold

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My son and I will be traveling from the South out to Montana via Spirit of New Orleans --> Empire Builder. We will have a sleeper. His medication has to be kept refrigerated. An ice pack won't last all 50 hours. Does anyone have experience with this and/or recommendations?
 
I have a insulated foil zip-lock type bag that the SCA fills with ice for me each morning. I then put that in a small (6 pack size) soft sided cooler bag. (I use the foil bag to minimize the effects of melting ice on the other items in the cooler bag.)
 
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