I too am looking for somewhere safe to stay in chicago. I am going to try and catch a Cubs game at Wrigley field whilst I am in town next May. Is there a safe neighborhood between the two or where would you suggest I stay.
Wrigley is in a safe area. You could also stay in Lincoln Park, which is just south of Wrigleyville/Lakeview.
What is your price range? When we go to Wrigley, we always stay at the Heart O'Chicago motel, which is in a neighborhood called "Andersonville". It has free parking, free Wi-Fi, and free breakfast, and it's on the Clark #22 bus line, which goes directly to Wrigley Field. The rooms aren't fancy, but they're the cleanest rooms I've ever stayed in. It looks like an old motel from the 1950s. They even use a ledger instead of a computer.

If you're willing to pay a bit more, I've had excellent luck with Hotwire. We've stayed in a few 4-5 star hotels in the Loop for around $125-175/night. Our most recent stay was at Hotel Sax, which we adored. Normally, it's $360/night, but we got it for $149/night through Hotwire.
Edited by Sorcha, 21 October 2012 - 04:30 PM.